Multi-omics signatures of the human early life exposome

Nature | Article | 21 November 2022

In this work, the research team aimed to associate the personal early life exposome, measured in 1301 mother–child pairs of the Human Early Life Exposome (HELIX) project, with deep molecular phenotype data assessed in childhood and defined by the blood methylome and transcriptome, plasma proteins, and serum and urinary metabolites. The analysis identified 1,170 significant associations (249 in pregnancy and 921 in childhood) which provide insights into potential biological responses and sources of exposure.

Read more